Written by: Dr. Robert Bard
Cancer Specialist, NYC)
In the mid-sixties, the medical community and the radiological society were dedicated to the pursuit of non-invasive screening and diagnostic protocols through MEDICAL IMAGING. Early mammography was established as a minimally invasive cancer screening protocol. Other imaging solutions like the MRI, Pet-CT and the ultrasound were also part of this global diagnostic movement. - (also see our list of cancer diagnostic solutions)
Meanwhile, early forms of genetic testing which began in the 1950's involved counting the number of chromosomes per cell. Deviations from the expected number of chromosomes (46 in humans) could lead to a diagnosis of certain genetic conditions such as trisomy 21 (Down syndrome) or monosomy X (Turner syndrome)....Genetic tests are performed on a sample of blood, hair, skin, amniotic fluid (the fluid that surrounds a fetus during pregnancy), or other tissue. 
In the spring of 2019, our network of immuno-oncologists have alerted us of a new advancement in cancer detection and genetic sequencing. The treatment community expressed enthusiasm over this "GRAIL" protocol in overwhelming comparison to the technologies available in the current market. 
Where the vast majority of cancer pursue the general presence of cancer, GRAIL's screening approach under the Galleri™ program offers a multi-cancer early detection test that promises to "detect over 50 types of cancers... over 45 of which lack recommended screening today — with a low false positive rate, through a single blood draw... GRAIL unique methylation-based technology preferentially targets the most informative regions of the genome and is designed to use its proprietary database and machine-learning algorithms to both detect the presence of cancer and identify the tumor’s tissue of origin."
“Today, the majority of cancers are found too late, when outcomes are often fatal, because most deadly cancers have no available screening tests,” says Josh Ofman, GRAIL CMO. “Current guideline-recommended screenings are critical, but in the United States they cover only five cancers and screen for a single cancer at a time.” 
By spring of 2020, news of GRAIL going public with investors like Johnson & Johnson, Arch Venture Partners and Amazon CEO Jeff Bezos. In fall of that same year, it was announced GRAIL would be acquired by Illumina, the company it was originally spun out from to pursue the development of its early detection technology. Other pharmaceutical companies such as Amgen, AstraZeneca, and Bristol Myers Squibb have also joined the growing list of partners.. 
An advancing movement in Multi-Cancer Early Detection (MCED) offers use of sophisticated technologies to identify signals of early cancer in blood and can detect a variety of cancers, many of which are potentially lethal and currently have no recommended screening tests. The ease and convenience of cancer detection via a single blood draw is an important added advantage that could help achieve better compliance than existing single-cancer screening tests. Still, the goal is not to have an MCED test replace the current cancer screening paradigm, but rather to complement existing single-cancer screening tests. (source- AJMC link)
• In a comparative response study, an MCED test identified a diversity of cancer signals with high specificity.
• The MCED test predicted the origin of the cancer signal with high accuracy across multiple cancer types.
• Results support the use of this MCED test on a population scale as a complement to existing single-cancer screening tests.
In this pre-specified, large-scale, clinical sub-study, the MCED test demonstrated high specificity and accuracy of CSO prediction and detected cancer signals across a wide diversity of cancers. These results support the feasibility of this blood-based MCED test as a complement to existing single-cancer screening tests. (source: Annals of Oncology link)
ROBERT L. BARD, MD, PC, DABR, FASLMS - Dr. Bard received the 2020 nationally acclaimed Ellis Island Award for his lifetime achievement in advanced cancer diagnostic imaging. He co-founded the 9/11 CancerScan program to bring additional diagnostic support to all first responders from Ground Zero. His main practice in midtown, NYC (Bard Diagnostic Imaging- www.CancerScan.com) uses the latest in digital imaging technology and has been also used to help guide biopsies and in many cases, even replicate much of the same reports of a clinical invasive biopsy. Imaging solutions such as high-powered sonograms, Power Doppler Histogram, Sonofluoroscopy, 3D/4D image reconstruction and the Power Doppler Histogram are safe, noninvasive, and do not use ionizing radiation.
GRAIL 101: THE NEXT GENERATION OF GENETIC DIAGNOSTICS & CANCER TRACKING
(Transcript from GRAIL educational video)
Cancer strikes one in two men and one in three women during their lifetimes and most cancers are detected too late. Often when the prognosis is poor and treatment options are limited, nearly 80% of those diagnosed with late stage cancer die within five years. If the cancer could be discovered earlier, prognosis could improve and treatment options could expand because only a few cancers are screened for many cancers can often grow undiscovered for years. In fact, 71% of cancer deaths are due to cancers with no recommended screening test. But what if there was a way to screen for multiple cancer types, with something as simple as a routine blood test inside every human body DNA fragments are routinely released from cells and circulate within our blood. These fragments often contain features that indicate the type of cell they originally came from including cancer cells. After extensive research grail determined the most promising way to detect cancer signals from this DNA in the blood and where in the body.
These signals came from by looking at one type of unique feature of DNA, methylation markers, grails, DNA sequencing, and machine learning technology allows us to recognize signatures for cancer by analyzing over 1 million of these potential methylation sites in the DNA fragments found in the blood. And after comparing thousands of cancer, patient blood samples with cancer free samples, we identified the ability to predict the presence of cancer. Recognizing this signature allows braille to determine whether cancer may be present. And if a cancer is present to detect its location within the body with high accuracy, with larger and more diverse datasets grail has continually improved the ability to predict when cancer is present and now has a validated multi cancer early detection test available to healthcare providers. The gallery test is complimentary to current cancer screening approaches and detects over 50 types of cancer. 45 of which have no recommended screening test today using a simple blood draw gallery detects cancers and healthcare providers can direct actionable next steps to confirm the diagnosis. Even before cancer has had a chance to spread early cancer detection has the potential to improve cancer survival because beating cancer starts with knowing you have it. Grail early detection for multiple cancers.
The gallery test is not detect all cancers. It should be used in addition to routine screening tests, false positives and false negatives can occur. The test is available by prescription only.
by Lt. Chris Conner/ Bedford (TX) Fire Dept.
As a career firefighter, I personally knew the risks of the job and accepted them if it meant helping others. Early in my career, firefighters that I worked with were getting cancer and losing their battles. I didn't have a full understanding why firefighters were getting cancer until one of my mentors in the fire service was diagnosed. Unfortunately, Keith did not overcome his battle with cancer and it became a personal mission for me to help other firefighters. I learned firsthand that cancer is not just a disease that affects the individual, but it also has affects on families and friends. I have initiated and proposed many cancer preventive policies in the fire service. Additionally, I created a non-profit organization to assist firefighters that are diagnosed with cancer.
2) AAAS/ Science magazine- TECHNOLOGY FEATURE "Catching cancer extremely early"- By Mike May/ Mar. 26, 2021 : https://www.sciencemag.org/features/2021/03/catching-cancer-extremely-early#:~:text=The%20scientists%20reported%3A%20%E2%80%9CPanSeer%20detects,of%20care%E2%80%9D%20(2)
3) Healthline: "Galleri is gathering widespread support" by Jamie Reno on March 17, 2021: https://www.healthline.com/health-news/this-new-test-can-detect-50-types-of-cancer-from-a-single-blood-draw#Galleri-is-gathering-widespread-support