Monday, March 22, 2021

STRAIGHT TALK GOT ME TO VACCINATE


Op Ed: ABOUT GETTING THE SHOT
By: Leopoldo Gratzi, Ed.D

NYCRA-NEWS launched the "GET THE SHOT" campaign, kicked off with by Dr. Richard Schulder (R) and the many front line health responders who posted their vaccination selfies on Linkedin.  Contrary to the very program I designed to bring prevention and safety to the public, I write this segment confessing my (then) conflicted thoughts about the vaccine.  The barrage of pros and cons from the media who all drove their hardline versions of "convincing truths" constantly fed trepidation and confusion in me.  As a publisher of health news, I wrestled daily with my social responsibility vs. my fears fueled by the daily data overload.

Adding to my struggling lack of faith was the challenge of getting the vaccine for my elderly family members (back in January of this year). Long waits, broken websites and insane lines for appointments turned into dis-appointments with zero inventory certainly took all the desire out of getting vacinated.


"CLEAR TALK FROM THE DOCS"
I became a medical publisher to offer Scientists, Doctors and Researchers an educational platform to impart their experience-based wisdom to the general public. After conducting enough interviews with medical professionals explaining in clear English WHY they trust the vaccine, I found great peace and personal value in their logic.  Their sensible guidance broke through my fears and questioning mind, such that this compelled me to share their viewpoints to others. But more than my public service, I also realized that I was gathering their views to quell my OWN resistance from getting the shot.

Front liners and essential workers are at the top of the list for the simple reason that their work does not lend itself the option to self-isolate.  If there was a group of people who understood infection, contamination and prevention, physicians make it their business to do their 'homework' on the vaccine- enough to personally support hoping to educate the skeptics, the nay-sayers and the fear-mongers.

I found the source of our divided community to stem from confusion  overwhelming flood of digital information vs. the the emotional and psychological tolls (from the pandemic) on the public. "I got the shot to get back to work, but I can empathize those who resist it -- it takes strength and a lot of  energy to TRUST anything (ie. the government) after a year of mask-wearing, half a million deaths and a life upside down!" - says Elizabeth Cristi, home health aide.

Speaking out to all public concerns, Dr. Stephen Chagares shared his own personal findings (through the use of 1st grade math) to verify why the vaccine is SAFE and NOT RUSHED- for himself, his family and for the community.  A talented educator to his patients, Dr. Chagares drives compelling statements with the help of reputable references to support herd immunity as a sound strategy for reversing the pandemic. "The very first recipients of the vaccine were healthcare personnel... the same people who treat and restore the ill. 


SPRING IS HERE
March 2021. US news reports 447 million doses have been administered at an estimated pace of 11 million doses a day- covering 1/4 of the US population. At least four companies are successfully manufacturing and distributing a tested and proven vaccine with more underway in the next few weeks. Appointments in vaccination sites are (now) happening on a next-day basis with no issues or delays.  Truly a different environment from January.

Sunday, 3/21 - Quietly sitting in the mandatory post-vaccination 15 minute waiting room, I reflected on how quickly and efficiently I got my shot (@ a CVS in Auburndale in Queens, NY).  With a strange calm, I first texted Dr. Chagares with a big smile underneath my double mask "I'm here because of your interview on the vaccine!" attaching my selfie (R), just like the ones my docs posted on social media. 

In closing, I see the vaccine resistance is a direct stand on our personal independence.  This is reflective on our cynicism and our unrelenting ability to question authority. But as a people, we also hold the ability to band together, self-motivate and shape our beliefs for the greater good- especially in times of crisis. Dr. Chagares and the many health responders who speak out or post their selfies getting the shot are clearly endorsing the return of our way of life and a healthy community.  If the pandemic challenge is earning public trust, "Straight Talk from the Docs" got one more subscriber to join the movement of social responsibility. 

This is US.


My Vaccination Debate - by: Anthony J. Carfang

I marvel at the wonders of modern medical science and its gifts to mankind.  However, I am even more amazed at the miraculous recuperative powers of the human body.  So much so that I absolutely hate to have anything foreign enter my system.  I avoid pills and supplements.  Until this year, I had never taken the flu shot!

My logic about the flu shot was simple: 1) follow all the health protocols and sanitary precautions, 2) avoid people with flu symptoms.  I further reasoned that I would have time to seek care if I did catch the flu.  It worked for decades.

Those assumptions don't work for Covid.  Asymptomatic spread makes it impossible to avoid the virus, even by diligently following the protocols.  Further, I've seen friends and relatives progress from mild symptoms to hospitalization in a matter of hours.  

That made a vaccine believer out of me.


ABOUT THE WRITER

Anthony Carfang is a board member of Survivingbreastcancer.org, a nonprofit organization committed to supporting those who have been touched by breast cancer. Whether you are caring for someone who has been diagnosed, know someone who has breast cancer, have been diagnosed yourself or carry one of the gene mutations, we understand that a breast cancer diagnosis can be life changing and overwhelming. Out of the need to navigate the uncertainty and the strong desire for connection, support, and resources, surivingbreastcancer.org was born.




REFERENCES

1) “Operation Warp Speed selects billionaire scientist’s COVID-19 vaccine for monkey tests” https://www.sciencemag.org/news/2020/06/operation-warp-speed-selects-billionaire-scientist-s-covid-19-vaccine-monkey-tests

2) How were researchers able to develop COVID-19 vaccines so quickly? https://news.uchicago.edu/story/how-were-researchers-able-develop-covid-19-vaccines-so-quickly

3) “How did we develop a COVID-19 vaccine so quickly?”  https://www.medicalnewstoday.com/articles/how-did-we-develop-a-covid-19-vaccine-so-quickly

4) “Fact check: The vaccine for COVID-19 has been nearly 20 years in the making” https://www.usatoday.com/story/news/factcheck/2021/01/21/fact-check-covid-19-vaccine-nearly-20-years-making/3873247001/

5) “A Timeline of COVID-19 Vaccine Development”  https://www.biospace.com/article/a-timeline-of-covid-19-vaccine-development/

6) National Geographic: “COVID-19 requires the world to consider 'unconventional approaches'” https://www.nationalgeographic.com/science/article/to-make-a-coronavirus-vaccine-we-may-need-to-deliberately-infect-people

7) https://www.bloomberg.com/news/articles/2021-03-12/u-s-hits-100-million-dose-mark-three-months-into-vaccine-push


Tuesday, March 9, 2021

FUCOIDAN: Anti-Cancer Functions + Inhibitor of Covid-19?

By: Dr. Robert L. Bard & Adrian Barrios  (NY Cancer Resource Alliance writing team)

A natural health ingredient known as FUCOIDAN has joined our western fight against cancer  -native to the cold temperate seas of China, Japan, Korea. According to Memorial Sloan Kettering Cancer Center, "Fucoidan is a complex polysaccharide found in many species of brown seaweed (including Undaria pinnatifida and Cladosiphon okamuranus Tokida).... shown to slow blood clotting. Laboratory studies suggest that it can prevent the growth of cancer cells and has antiviral, neuroprotective, and immune-modulating effects."

In addition to its anticancer & anti-tumor components, Fucoidan has also shown effects as an antioxidant, anti-angiogenic, antiviral, and anticoagulant activities. [5]  These properties have captured the current interest of clinicians determined to produce treatment solutions for the complex symptoms of the CoronaVirus.  At the advent of public recognition of the drug REMDESEVIR (a widely popularized drug for its qualities as an immunomodulator), recent news headlines are highlighting major comparisons and competing statements with "the Seaweed extract to out-perform Remdesivir as a Covid inhibitor".  Also, Fucoidan has been compared to HEPARIN, an anticoagulant for its chemical composition of sulfated polysaccharide.

REMDESIVIR: Is recognized as the first approved drug to be effective against SARS-CoV-2. [8] In a clinical study (on 8/6/2020) by The National Institute of Allergy and Infectious Diseases (NIAID)- a branch of the NIH, tests for the efficacy of the antiviral Remdesivir + the interferon Beta-1a is underway a potential COVID-19 treatment.  "Laboratory studies suggest... type 1 interferon can inhibit SARS-CoV-2 and two closely related viruses, SARS-CoV and MERS-CoV. In addition, two small randomized controlled trials suggest that treatment with interferon beta may benefit patients with COVID-19." [6]

First isolated by Dr. Harvey Kylin in 1913 (Uppsala University, Sweden), Fucoidan has been known to come from different species of brown algae and seaweed, carrying different biochemical properties[0] Fucoidan's bioactivity has been linked to its anti-cancer properties including the induction of inflammation through the immune system, oxidative stress and stem cell mobilization[1].

The anti-cancer property of fucoidan has been demonstrated in vivo and in vitro in different types of cancers. For the Immune System, Fucoidan has been recognized to increase the number of natural killer cells and increase in the number of cytotoxic T-cells. Tests/Trials of fucoidan's effects on dendritic cells showed that the stimulation of CTLs was more effective in fucoidan-treated DCs which exerted a high level of specific lysis of breast cancer cells [2]. In addition, Fucoidan has also been known to carry (immunomodulatory) protective effects against the side effects from chemotherapies or radiation.

 

(Geographical distribution of Okinawa mozuku.)

ANTI-INFLAMMATION
Inflammation and immunity play important roles in the development of tumorigenesis [7]. Current epidemiological and preclinical results strongly support an anti-inflammatory approach to treating cancers. Several therapeutic agents targeting cancer-derived inflammatory responses and related signaling molecules, cytokines, transcription factors, and immune cells are being developed and tested [7.5]. Inflammation, cancer recurrence and cancer metastasis have a complicated relationship. Inflammatory responses play important roles in tumor development, including metastasis [9].

In mid-2018, an oral administration and absorption study of Mozuku fucoidan in 396 Japanese volunteers was performed. [10]. The results showed that fucoidan absorption in humans is extremely low; the fucoidan concentration after oral administration was approximately ten times higher in urine than in serum, confirming the intestinal absorption of Mozuku fucoidan in humans. The results indicated that volunteers living in Okinawa prefecture have the maximum value of urinary fucoidan, significantly higher estimated urinary excretion of fucoidan by place of residence, and significantly higher Mozuku fucoidan consumption habits compared with those living outside Okinawa prefecture. However, the biological mechanisms of fucoidan absorption across the intestinal tract need to be further investigated.


FROM THE SOURCE 

This section is directly sourced from an interview with Dr. Yoshiyuki Miyazaki at the NPO Research Institute of Fucoidan in Fukuoka, Japan.  Dr. Miyazaki received his PhD in Food Science and Biotechnology (2003) at Kyushu University.  He achieved a post-doctoral fellowship of JST, and then worked on basic research work on the immune regulation in infectious and allergic diseases at Saga University as associate professor (2004-2009). Since 2014, he started FUCOIDAN research on anti-cancer and immune regulatory effects to improve “Quality of Life” at NPO Research Institute of Fucoidan as chief researcher (2010-2011). After receiving a research fellowship (2014-2016), he assumed an associate professorship in the Laboratory of Bioactive Polysaccharide Analysis in Kyushu University where he performed research work on mechanisms in the regulation of intestinal immunity by fucoidan to enhance anti-tumor immunity (2016-present)

FUCOIDAN AND THE IMMUNE SYSTEM

Fucoidan is extracted using a special filtration membrane, and components with a molecular weight of 10,000 or less (impurities such as salts, heavy metals) are removed during the extraction process. As in the case of a research program from Keio University, synthesis of Fucoidan [1][2][3], is possible at the laboratory level, but has not yet been put to practical use.

We emphasize that the actual physiological action of Fucoidan is not "anti-cancer" that suppresses the growth of cancer cells with direct interaction, but "immune improvement" that is a host defense mechanism to prevent tumor growth. It is believed that Fucoidan activates the human body's natural immune mechanism that leads to the treatment of diseases that progress with a measurable decrease in immunity. I have studied on the mechanism of immune regulation by Fucoidan since 2010 as chief researcher in NPO Research Institute of Fucoidan, and now continuing in Laboratory of Bioactive Polysaccharide Analysis, Faculty of Agriculture in Kyushu University (2016. 4 - present, associate professor). Through 10 years of research, I have found unique and certain immuno-potentiating effects of Fucoidan. I hope that immune enhancement by Fucoidan may enhance the host resistance against SARS-CoV-2 and vaccine efficacy for Covid-19 treatment.

Fucoidan is not classified as a drug, therefore is not currently applied as a measurable treatment solution for the pandemic. (Development of vaccines for COVID-19 is desired to improve the current situation.) Fucoidan may, however be used as an effective supplement to immune enhancement in the vaccination.


EFFICACY & GLOBAL ACCEPTANCE

Some human trials have revealed useful physiological effects of Fucoidan improving medical treatment. However, in my opinion, there remains varied challenges in pharmaceutical approval of Fucoidan (due to the reasons described above)  unless mass-production of synthetic Fucoidan would be developed. Meanwhile, laboratory studies indicated success in synthesizing Fucoidan at the Keio University research program-- whereby the effects of oligofucosides, synthetic sulfated oligosaccharide with backbone structures of Fucoidan have been investigated on cancer cell growth [1][2] and influenza virus infection [3].

Currently, the scientific and medical communities have no conclusive evidence of therapeutic effects of Fucoidan on SARS-CoV-2. However, Fucoidan has been known to prevent dengue virus infection by direct interaction with viral envelope glycoprotein[4]. Furthermore, it was reported that Fucoidan possibly control influenza virus infection by augment immune responses, especially virus neutralizing antibody production[5]. In this context, we previously reported that Fucoidan derived from Undaria pinnatifida augmented immunoglobulin (IgA, IgG and IgM) production by mouse spleen lymphocytes[6]. So, we are believing that Fucoidan have sure physiological activities to reinforce vaccine efficacy.


ACTIVE COMPONENTS

Fucoidan is a natural ingredient with complex composition- whereby its pharmacological component is not a single chemical substance like a DRUG or MEDICINE. Fucoidan is a kind of polysaccharide, but similar polysaccharides have β-glucan derived from mushroom. A purified β-glucan preparation named "Lentinan" has uniform composition and is approved as a drug for gastric cancer in Japan. In contrast, "Fucoidan" cannot be expected to have medicinal action by single component like β-glucan, so it is used as a naturally occurring SUPPLEMENT like Kampo rather than pharmaceuticals.

The source plant of Fucoidan is not only Undaria pinnatifida but also Cladosiphon okamuranus Tokida-  the most major species of Mozuku Fucoidan (Okinawa mozuku in Japanese name).

Physiological properties of Fucoidan has had extensive presence in the health and wellness communities, where scientific information is accessible in many articles- including Therapies from Fucoidan; Multifunctional Marine Polymers[7]   A protective effect of Fucoidan against side effects from chemotherapy with FOLFOX or FOLFIRI has been investigated in the following report; Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer[8]


GEOGRAPHIC SOURCING

I believe Fucoidan is related to brown algae habitat and food culture. In Japan, it can be seen that seaweed has been used for health since ancient times, since there is a description in "本草和名:Honzo Wamyo", the oldest existing drug dictionary in Japan compiled around the year 900 AD. In Japan, where the country faces the sea, a food culture that incorporates seafood into the diet takes root, and it is thought that aquaculture of seaweeds and the research have advanced.

Seaweeds are classified into three groups, "red algae", "green algae" and "brown algae", and Fucoidan is a component contained only in brown algae. Other plants do not have Fucoidan.

Among the brown algae, only Fucoidan contained in Mozuku (Cladosiphon okamuranus Tokida), Mekabu (Undaria pinnatifida), and Gagomecomb (Kjellmaniella crassifolia) has the Japan Health Food Authorization (JHFA)[9] quality standards and can be certified as conforming.  The association conducts work that contributes to the health promotion of the Japanese nationals, such as collecting and spreading information on food with health claims and operating JHFA and other certifications.

According to reports, response of Fucoidan appears to affect a higher rate of residents of the sourced area (Japan) than any other part of the globe.  The research team at "Station Biologique de Roscoff", research and educational institute for marine biology and oceanography in France, reported that Japanese can decompose some kinds of polysaccharides contained in seaweed, because their enterobacteria (Bacteroides plebeius) took up gene for degrading enzyme from other marine microorganisms (published in British scientific journal "Nature" at April 8, 2010). Even within Japan, there are regional differences as with food culture, so I believe it is highly possible that there will be regional differences in the effects of Fucoidan around the world.


References:

1) Systematic synthesis of sulfated oligofucosides and their effect on breast cancer MCF-7 cells (https://pubs.rsc.org/en/content/articlehtml/2014/cc/c4cc03544e)

2) Systematic synthesis of low-molecular weight Fucoidan derivatives and their effect on cancer cells (https://pubs.rsc.org/en/content/articlehtml/2015/ob/c5ob01634g)

3) Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection (https://pubs.rsc.org/en/content/articlehtml/2018/cc/c8cc03865a)

4) Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga (https://www.sciencedirect.com/science/article/pii/S0006291X08016562)

5) Supplementation of Elderly Japanese Men and Women with Fucoidan from Seaweed Increases Immune Responses to Seasonal Influenza Vaccination (https://academic.oup.com/jn/article/143/11/1794/4637681)

6) The enhancing effect of Fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes

(https://www.tandfonline.com/doi/full/10.1080/09168451.2014.930323)

7) "Therapies from Fucoidan; Multifunctional Marine Polymers"

https://www.mdpi.com/1660-3397/9/10/1731/htm

8) Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer  https://www.spandidos-publications.com/10.3892/ol.2011.254

9) JHFA is a certificate given to health foods that comply with voluntary food standard set by the Japan Health and Nutrition Food Association (JHNFA). JHNFA is a public interest incorporated foundation authorized by the Cabinet Office with the aim of promoting public health (http://www.jhnfa.org/english-info.html).




The above results show that fucoidan, whether through basic in vitro to in vivo research studies or clinical trials in humans, has been proven to produce effect of adjuvant therapy on cancer treatment. This allows molecular mechanisms in cancer research to be applied in adjuvant treatment, in line with the pursuit of translational medicine and the mindset of establishing a direct link between basic medical research and clinical application.

In conclusion, understanding the mechanisms underlying the anti-cancer effects of fucoidan, the advantages of combining fucoidan with therapeutic agents in the treatment of cancers, and the pharmacological limitations of fucoidan will aid the development of more informed approaches to treating cancers and may improve current clinical outcomes for cancer patients.


References:

0. 4. Kylin H. Biochemistry of sea algae. HZ Physiol. Chem. 1913;83:171–197. doi: 10.1515/bchm2.1913.83.3.171. [CrossRef] [Google Scholar]

1. Kwak J.Y. Fucoidan as a marine anticancer agent in preclinical development. Mar. Drugs. 2014;12:851–870. doi: 10.3390/md12020851. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

2. Hu Y., Cheng S.C., Chan K.T., Ke Y., Xue B., Sin F.W., Zeng C., Xie Y. Fucoidin enhances dendritic cell-mediated t-cell cytotoxicity against ny-eso-1 expressing human cancer cells. Biochem. Biophys. Res. Commun. 2010;392:329–334. doi: 10.1016/j.bbrc.2010.01.018. [PubMed] [CrossRef] [Google Scholar]


Main sources:

4. Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413214/

5. Fucoidan Extracted from Undaria pinnatifida: Source for Nutraceuticals/Functional Foods   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164441/#B4-marinedrugs-16-00321

6. NIH clinical trial testing remdesivir plus interferon beta-1a for COVID-19 treatment begins    https://www.nih.gov/news-events/news-releases/nih-clinical-trial-testing-remdesivir-plus-interferon-beta-1a-covid-19-treatment-begins

7. Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361:1314–1315

7.5 Grivennikov SI, Greten FR, Karin M (2010) Immunity, Inflammation, and Cancer. Cell 140(6):883–899

8. FDA: Frequently Asked Questions on the Emergency Use Authorization for Remdesivir for Certain Hospitalized COVID-19 Patients -  https://www.fda.gov/media/137574/download

9. SpringerOpen: https://clintransmed.springeropen.com/articles/10.1186/s40169-019-0234-9 (open access)

10. Kadena K, Tomori M, Iha M, Nagamine T (2018) Absorption study of mozuku fucoidan in japanese volunteers. Mar Drugs 16:254. https://doi.org/10.3390/md16080254

11. https://www.mdpi.com/1660-3397/16/8/254  Posted by Awareness 4aCure at 11:24 AM   



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