SOURCE: NIH National Cancer Institute
There are many types of cancer treatments. The types of treatment that you have will depend on the type of cancer you have and how advanced it is. Some people with cancer will have only one treatment. But most people have a combination of treatments, such as surgery with chemotherapy and/or radiation therapy. You may also have immunotherapy, targeted therapy, or hormone therapy.
Clinical trials might also be an option for you. Clinical trials are research studies that involve people. Understanding what they are and how they work can help you decide if taking part in a trial is a good option for you.
When you need treatment for cancer, you have a lot to learn and think about. It is normal to feel overwhelmed and confused. But, talking with your doctor and learning all you can about all your treatment options, including clinical trials, can help you make a decision you feel good about. Our Questions to Ask Your Doctor About Treatment may help.
Surgery: When used to treat cancer, surgery is a procedure in which a surgeon removes cancer from your body. Learn the different ways that surgery is used against cancer and what you can expect before, during, and after surgery.
Radiation Therapy: is a type of cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. Learn about the types of radiation, why side effects happen, which ones you might have, and more.
Chemotherapy: is a type of cancer treatment that uses drugs to kill cancer cells. Learn how chemotherapy works against cancer, why it causes side effects, and how it is used with other cancer treatments.
Immunotherapy to Treat Cancer- helps your immune system fight cancer. Get information about the types of immunotherapy and what you can expect during treatment.
Targeted Therapy is a type of cancer treatment that targets the changes in cancer cells that help them grow, divide, and spread. Learn how targeted therapy works against cancer and about common side effects that may occur.
Hormone Therapy is a treatment that slows or stops the growth of breast and prostate cancers that use hormones to grow. Learn about the types of hormone therapy and side effects that may happen.
Stem Cell Transplants are procedures that restore blood-forming stem cells in cancer patients who have had theirs destroyed by very high doses of chemotherapy or radiation therapy. Learn about the types of transplants, side effects that may occur, and how stem cell transplants are used in cancer treatment.
Precision Medicine helps doctors select treatments that are most likely to help patients based on a genetic understanding of their disease. Learn about the role precision medicine plays in cancer treatment, including how genetic changes in a person's cancer are identified and used to select treatments.
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
Thursday, July 18, 2019
Reflectance Confocal Microscopy (RCM)- The latest Imaging Advancement for Dermatologists
DR. MANU JAIN, Optical Imaging Specialist at Memorial Sloan Kettering Cancer Centre (MSKCC) Department of Dermatology provides great insight on the advantages of Reflectance Confocal Microscopy (RCM) for the diagnosis of skin cancers, in vivo.
RCM is a form of in vivo microscopy— “histopathology-like” diagnosis without doing a biopsy. It offers several advantages over conventional light microscopy, including imaging of tissue in vivo and ability to provide bedside diagnosis. In addition to its applications in dermatology it can also be applied for oral cancers. Meanwhile, we call this application ‘optical biopsy’. Microscopy is actually what's paving the way for digital imaging in dermatology. Before this it was the naked eye and magnifying lens.
THE POWER OF LIGHT
As ultrasound is recognized for being non-invasive and
radiation free, so is optical imaging – gathering cellular and nuclear
epidermal and superficial dermal information through the use of LIGHT and
laser. It penetrates the skin to reach an
estimated 200 micron in depth - good enough in dermatology to diagnose skin
cancers like melanoma, basal cell carcinoma, and squamous cell carcinoma.
Because most tumors that appear originates at the dermo-epidermal junction
(around a hundred-micron depth from skin surface). In addition to morphological
and cellular details, RCM also provides
information on the dynamic phenomenon of the
blood flow very clearly.
This innovation relies solely on reflectiveness of various
tissue structures in the skin, illuminating and magnifying images by relying on
the light planes. “Your skin is like a mirror and when you shine light on the
mirror, whatever absorbs all the light becomes dark and whatever reflects all
the light appears bright”.
"I think it could be interesting to explore the option
of combining confocal microscopy with ultrasound because ultrasound can give us
the doppler information and also the depth is a very good with ultrasound…
which we miss with confocal microscopy.
So that would be really great. Like they have done with confocal and
optical coherence tomography."
Her professional
focus is to teach RCM to dermatologists and dermatopathologists. For the large institutions, it’s fairly
affordable and cost-effective as it takes only 15 minutes or 20 minutes to do
one lesion. That means a patient gets
scanned and diagnosed at the same time. This saves a lot of time for the
patient at the end of the day because the patient doesn't have to wait for the
biopsy report for week.
According to Dr. Jain's original bedside diagnosis study,,
RCM has shown remarkable sensitivity (~90%) and specificity (~70%) in hands of
a novice, within a short interval of 16 months [2] , for skin cancers.. Several studies reported RCM imaging to
achieve sensitivity of 70–92% and specificity 84–88% for melanocytic lesions
[3] and sensitivity of 100–92% and specificity 85–97% for non-melanocytic skin
lesions . . "As an example, we’re examining a patient's new mole with
confocal microscopy and if we are suspicious that it might be melanoma, we can
use dermoscopy and confocal together to improve the accuracy of diagnosis.
Although the sensitivity of RCM has not much changed over
dermoscopy but the specificity is two times superior—translating into marked
decrease in benign biopsies.
Thanks to the developmental expertise of Dr. Milind
Rajadhyaksha (member of the faculty of Memorial Sloan Kettering Cancer Center),
the IN VIVO CONFOCAL MICROSCOPY is fast becoming the new standard in dermal
non-invasive imaging. Originally
conceptualized with his mentors at MD Anderson (renowned physicist Dr. Robert
Webb and dermatologist/laser pioneer Dr. Rox Anderson), the team sought better
ways to detect skin cancers while reducing the need for biopsies in real time
at the bed-side. At the time, biopsy and
pathology were the standard approach for detecting and diagnosing skin
lesions. The demand for advancing
diagnostic imaging was a call from the 5 million+ new cases diagnosed in the US
each year and another million cases detected in Europe, UK, Australia, other
regions of the world.
Milind (as he prefers to be called) described how the RCM
works in simplified terms: “We start with a bright light source… in our case
it's a laser. We focus the laser down to
a very tiny spot inside the skin and we move the spot around in 2 dimensions so
we create essentially a plane of illumination by moving that spot. Imagine
having a flashlight which you point at a wall and now you move the flashlight
back and forth, sideways and up and down until you can illuminate the entire
wall. Similarly, we ‘paint’ a single
plane within tissue with focused laser spot and we collect light from each
location that the spot illuminates and that we can use that to produce an
image. You can essentially create an image or a picture of a single layer of
cells or layer of tissue within skin.”
Milind states having built the original laboratory bench top
portion in the early 1990’s and continued the expansion of the technology with
MSKCC since 2005. He has been involved with advancing both the IN vivo (means
directly on the patient) and the EX vivo microscope (referring to any fresh
tissue that has been removed from the patient, ie. biopsy) to do faster imaging
over large areas. Besides looking at skin cancers, this technology is set up
over a mic top with a probe that can allow for imaging inside the oral cavity
looking for oral cancers. “We've done a lot of work in imaging to guide
treatment, surgeries and to guide laser ablations at Memorial for more than a
decade.”
References:
1) Current Procedural Terminology, Professional Edition. Chicago IL: American Medical Association; 2016. The preliminary physician fee schedule for 2017 is available at https://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/PhysicianFeeSched/PFS-Federal-Regulation-Notices-Items/CMS-1654-P.html
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
Thursday, July 11, 2019
A REVIEW OF TOXIC COMPOUNDS FROM EMERGENT FIRE ZONES
© Copyright 2019 - The Biofoundation for AngioGenesis R&D / IntermediaWorx inc. All Rights Reserved. Published for the NY Cancer Resource Alliance (NYCRA), AwarenessforaCure.org and HealthScanNYC.org
FOREWORD
By Dr. Robert L. Bard, cancer diagnostic specialist (NYC)
After a decade past the 9/11 disaster, news broke of unique and advanced cases of CANCER arising in droves. A growing number of the same individuals exposed to the toxic fumes and plumes of hazardous particles in the danger zone have recently contracted aggressive cases of CANCER and were in immediate demand for medical care and desperate need for advanced research and support.
This spike in cases can only come from ‘dormant’ cells or recurrence (usually with a vengeance) – such as cases of cancer tumors in the lung, liver, prostate, kidney, brain, skin and even the eye. To troubleshoot each case, it would be advantageous to take a crash course in toxicology and to recognize the chemical compounds that BATHED all responders during the event. Understanding these chemicals can help us pursue their behaviors (on the body) and their long and short term effects.
As part of our evaluation of all occupational illnesses contracted by first responders, we enter the world of TOXICOLOGY- the branch of science focused on the effects and detection of poisons. It is also the discipline overlapping chemistry, biology and pharmacology- studying the adverse effects of chemical substances on living organisms. In pursuit of first responders’ safety as far as chemical effects on the body, we connected with Professor David Purser of the Hartford Environmental Research (UK), a renowned toxicology expert who conducted major reviews on fire-exposed carcinogens published worldwide. “9/11 was unusual in that a major environmental hazard resulted from the dust cloud released as and after the Towers collapsed,” says Prof. Purser. “The dust inhaled by responders at the time, and afterwards working at the site, has resulted in serious ongoing and developing health conditions and to this day.
For fires in general, there is also increasing evidence and concern regarding FF exposure to carcinogens, especially from soot contamination to skin and clothing following attendance at incidents and during training.” An abstract from Prof. Purser’s latest presentation – “ Toxins Including Effects of Fire Retardants, During Fires and Post-Fire Investigation Activities” indicates a remarkable breakdown of some of the major toxins and carcinogenic compounds that the average firefighter would be exposed to.
Below is a list of common toxic elements found in active fires and post-fire investigations that first responders have been known to be exposed to.
For fires in general, there is also increasing evidence and concern regarding FF exposure to carcinogens, especially from soot contamination to skin and clothing following attendance at incidents and during training.” An abstract from Prof. Purser’s latest presentation – “ Toxins Including Effects of Fire Retardants, During Fires and Post-Fire Investigation Activities” indicates a remarkable breakdown of some of the major toxins and carcinogenic compounds that the average firefighter would be exposed to.
Below is a list of common toxic elements found in active fires and post-fire investigations that first responders have been known to be exposed to.
• (2,3,7,8) Tetrachloro ..-dibenzodioxin • Acrolein • Aldehydes • Asbestos • Benz[A]Anthrene • Benzene • Benzo[A]Pyrene • Carbon Fibre • Carbon Monoxide • Carbonyl Fluoride (COF2) • Ceramic |
• Crotonaldehyde • Dibenzofurans • Dioxins • Formaldehyde • Furans • Histone (H3.3) • Hydrochloric Avid (Hcl) • Hydrogen Cyanide (HCN) • Hydrogen Fluoride (HF) • Isocyanates • Metal Particulates |
• Metals: Lead (Pb) & Cadmium (Cd) • Nitrogen Oxides (Nox) • Organic Irritants • Phenol • Phosphorous/Phosphate (P04) • Polyaromatic Hydrocarbons • Polychlorinated Biphenyls (Pcbs) • Polycyclic Aromatic Hydrocarbon – (Pahs) • Styrene • Sulfur Dioxide (SO2) |
According to Prof. Purser’s presentation on “Fire Retardants and their Potential Impact on Fire Fighter Health” ** the highest and most active toxins threatening survival during or immediately after a fire are:
• ASPHYXIANT GASES: CO, HCN, CO2 , low oxygen
• IRRITANTS/ ACID GASES : HCl, HBr, HF, COF2 , H3 PO4, SO2 , NOx
• ORGANIC IRRITANTS: acrolein, formaldehyde, crotonaldehyde, phenol, styrene
• PARTICULATES: especially ultrafine particles + metals
These toxins are usually found within active fire zones- either inside the fire event itself or downwind plume in the form of residues and soot or lethal fragments activated at high temperatures or in airborne smoke. These asphyxiant gases, irritants and particulates are the main causes of injury and death of fire victims exposed to high concentrations inside burning buildings. Asphyxiant gases cause collapse with loss of consciousness during a fire, leading to death if exposure continues. Irritants and smoke particulates cause pain to the eyes and lungs, with breathing difficulties, which inhibit escape during a fire and can lead to lung inflammation and edema within a few hours of rescue, which can also be fatal. Those surviving may make a good recovery or suffer long term neurological or cardio-respiratory health effects, depending on the severity of the exposure. Those most at risk from these effects at the fire scene are building occupants and emergency responders not protected by breathing apparatus.
Beyond the immediate fire zone, especially outside a burning building, or during wildfires, these toxic smoke products are considerably diluted by mixing with outside air, so are generally not immediately life-threatening. The main hazards to unprotected persons exposed to the diluted smoke plume in the surrounding area are health risks from inhalation of smoke irritants and soot particulates, or from inhalation of mineral particles and fibers. The immediate effects of exposure are mainly eye and throat irritation, with a sore throat and cough in some cases over a period of a few days, although persons with pre-existing respiratory or circulatory health conditions may be more severely affected. Longer term health hazards following a single exposure may result from inhalation of sensitizers (such as isocyanates or formaldehyde), which can cause asthma, or from some mineral dusts and fibers, which may remain in the lungs. Health risks from exposure to carcinogens during a single incident are generally low, although the World Trade Center dust and some chemical fires may be exceptions.
Health risks to firefighters result mainly from repeated exposures to inhalation of smoke toxicants and contact with soot deposits. These contain a wide variety of carcinogens, so that cumulative exposure over years may present an increased cancer risk. The hazards arise from inhalation of smoke, soot or mineral fibers, but also from soot contamination of skin or clothing. This can result in dermal, inhalation or oral ingestion, resulting in increased exposure to carcinogens, including dioxins and dibenzofurans, during post-fire activities. Halogenated fire retardants (especially chlorine and bromine systems), present possible increased health risks to fire victims and firefigthers during fires due to inhibition of combustion in the vapor phase resulting in inefficient combustion with an increase in yields of toxic carbon and nitrogen compounds, in addition to the formation of acid gases, dioxins and dibenzofurans under all fire conditions..**
Beyond the immediate fire zone, especially outside a burning building, or during wildfires, these toxic smoke products are considerably diluted by mixing with outside air, so are generally not immediately life-threatening. The main hazards to unprotected persons exposed to the diluted smoke plume in the surrounding area are health risks from inhalation of smoke irritants and soot particulates, or from inhalation of mineral particles and fibers. The immediate effects of exposure are mainly eye and throat irritation, with a sore throat and cough in some cases over a period of a few days, although persons with pre-existing respiratory or circulatory health conditions may be more severely affected. Longer term health hazards following a single exposure may result from inhalation of sensitizers (such as isocyanates or formaldehyde), which can cause asthma, or from some mineral dusts and fibers, which may remain in the lungs. Health risks from exposure to carcinogens during a single incident are generally low, although the World Trade Center dust and some chemical fires may be exceptions.
Health risks to firefighters result mainly from repeated exposures to inhalation of smoke toxicants and contact with soot deposits. These contain a wide variety of carcinogens, so that cumulative exposure over years may present an increased cancer risk. The hazards arise from inhalation of smoke, soot or mineral fibers, but also from soot contamination of skin or clothing. This can result in dermal, inhalation or oral ingestion, resulting in increased exposure to carcinogens, including dioxins and dibenzofurans, during post-fire activities. Halogenated fire retardants (especially chlorine and bromine systems), present possible increased health risks to fire victims and firefigthers during fires due to inhibition of combustion in the vapor phase resulting in inefficient combustion with an increase in yields of toxic carbon and nitrogen compounds, in addition to the formation of acid gases, dioxins and dibenzofurans under all fire conditions..**
Reference:
** Prof. David Purser's presentation on Toxic Hazards to Fire Fighters, Including Effects of Fire Retardants, During Fires and Post-Fire Investigation Activities (NIST), Gaithersburgh MD on 9/30/2009 https://www.nist.gov/sites/default/files/documents/el/fire_research/4-Purser.pdf
“IT ALL STARTS AT THE LUNGS"
Historical Patterns of Carcinogenic Reactions from Environmental Disasters by: Dr. Jesse Stoff
If you review the victims of a disaster such as the radioactive fallout in CHERNOBYL, then compare it to the dust from the 911 catastrophe, you can find a similar behavior as far as how fatalities come to appear within a certain timeline. There’s the initial contamination that results in immediate illnesses- and then there’s a major wave of cancer cases that arise a decade later. These cancers are delineated on the CDC website and are occurring, undoubtedly, because of the mixture of toxins that people have been exposed to. The volume of these toxins are absorbed into their bodies since 9/11 (while working with the clean-up efforts) and can't get rid of them.
We are seeing patients with very unusual blood borne cancers that have had very unusual genetic profiles -undoubtedly because of the unusual combination of carcinogenic toxins that people were exposed to that have been lingering in their system for so many years. We're also seeing a marked increase in Monoclonal Gammopathies (MGUS) and Myelofibrosis which is progressive damage to the bone marrow that itself can become a cancerous process. We're seeing many people suffering changes to the structure and functioning of their immune system even without yet developing a cancer but for those kinds of changes their risk of developing skyrockets. Also, because of the shifting in their immune system we see a significant increase in the level of different kinds of allergies (including environmental based) that have become more prevalent and worse than before the exposure to this kind of toxic material.
In essence, the destruction and suffering continues.
by Capt. Richard
Marrone (9/11 Responder)
"It was just everywhere. The DUST was so thick it would dry your eyes out. You couldn't breathe. As EMS, that was a lot of what we were doing was just constantly cleaning people's eyes out. There's nothing you can do to get away from it. I know what was in those particulates--it was asbestos, it was concrete, it was human remains, metals and any possible contamination in a fire... it was all there. Nobody was protected. Even the firefighters who had self-contained breathing apparatus, you're only getting 15 or 20 minutes maximum on those cylinders, and there just wasn't enough to keep constantly replacing them. The police officers and EMS personnel were using surgical masks, which basically provided no protection whatsoever. We mostly treated rescue workers on site due to the dust-- eyes and stuff like that. There really wasn't enough eye or respiratory protection, so anybody that became a patient post-collapse was due to the contamination and the toxins of 9/11." |
Following the logical path of carcinogen, one would start from how environmental contaminants would make their way into the body; through the respiratory ports. As seen in the toxicology section of this article, these foreign substances range from particulates like metals and acids to microfragments to molecular-sized compounds whose behaviors vary from mild irritants to lethal poisons. More often than not, these compounds can trigger cell mutations in our physiology as well as attack our very immune system to penetrate our defenses for tumors to grow.
Our responders’ health report brought us to interview Pulmonary and Sleep Medicine Specialist Dr. Mayank Shukla (NYC) who helped identify the various diagnostics and screening procedures for first responders often start with a Pulmonary Function Test to study a patient’s airway size, and then a Bronchodilator Challenge Test to identify and distinguish between asthma and COPD. Another protocol for patients exposed to airborne contaminants is examining airway resistance and looking for Upper Airway Resistance Syndrome (UARS), Sleep Apnea and other breathing disorders caused by an impairment of the airway size.
The concern for the responder’s air passage brings telltale signs of possible impending issues based on their condition that brings warning signs of what may lie ahead- in the lungs, the bloodstream etc. There's another test which is available called NIOX designed for a patient to have allergy component or asthma that also is very sensitive, to look at the lung inflammation for these patients.
During airway inflammation, higher-than-normal levels of nitric oxide (NO) are released from epithelial cells of the bronchial wall. 4 The concentration of NO in exhaled breath, or fractional exhaled nitric oxide (FeNO), can help identify allergic/eosinophilic inflammation, and thereby support a diagnosis of asthma when other objective evidence is lacking. (See NIOX.com)
There are other testing available which helps us to do a direct visualization of the upper and lower levels. For example, there's the bronchoscopy for the lungs and air passages and then there's the laryngoscopy to visualize the nasal cavity, the sinus, sinusitis, the larynx, because many of these patients have acute or chronic laryngitis because getting exposed to the several toxins. Also, many of them have gastro esophageal reflux, so when you look at that endoscopy, you can realize that this patient have, you know, chronic inflammation of the, not only for a lower airway, but also with upper airway as well.
The concern for the responder’s air passage brings telltale signs of possible impending issues based on their condition that brings warning signs of what may lie ahead- in the lungs, the bloodstream etc. There's another test which is available called NIOX designed for a patient to have allergy component or asthma that also is very sensitive, to look at the lung inflammation for these patients.
During airway inflammation, higher-than-normal levels of nitric oxide (NO) are released from epithelial cells of the bronchial wall. 4 The concentration of NO in exhaled breath, or fractional exhaled nitric oxide (FeNO), can help identify allergic/eosinophilic inflammation, and thereby support a diagnosis of asthma when other objective evidence is lacking. (See NIOX.com)
There are other testing available which helps us to do a direct visualization of the upper and lower levels. For example, there's the bronchoscopy for the lungs and air passages and then there's the laryngoscopy to visualize the nasal cavity, the sinus, sinusitis, the larynx, because many of these patients have acute or chronic laryngitis because getting exposed to the several toxins. Also, many of them have gastro esophageal reflux, so when you look at that endoscopy, you can realize that this patient have, you know, chronic inflammation of the, not only for a lower airway, but also with upper airway as well.
SPECIAL CONTRIBUTORS:
1) Professor David Purser CBE, Toxicologist from the Hartford Environmental Res. (Hatfield, UK)
2) Dr. Mayank Shukla - (www.drmayankshukla.com/) pulmonologist
3) Dr. Robert Bard - AngioFoundation.org, bardcancercenter.com/ contributing writer
4) Dr. Jesse Stoff - publisher for awarenessforacure.org/, imofny.com contributing writer
5) Sal Banchitta- Ret FDNY / First Responders Cancer Awareness Sr. Ambassador
6) Captain Richard Marrone (ret. FDNY EMT / Vol. Long Island Firefighter
6) Kevin P. Coughlin - 9/11 Photography, www.kevinpcoughlin.com/
7) NIOX.COM
Monday, May 27, 2019
ITALIAN CONTRIBUTIONS TO ADVANCED CANCER IMAGING & DIAGNOSTICS
By: Dr. Robert Bard (Cancer Imaging Historian)
Edited by: Prof. Rodolfo Campani
THE BIRTH OF MEDICAL RADIOLOGY
Since the German discovery of the X-Ray in 1890, scientists worldwide found the drive to mobilize diagnostic science into a non-invasive direction. Scanning technology carried the potential to save lives by enabling images of physiological issues underneath the skin non-invasively- or without any cutting. But it wasn't until 1977 that the results of radiologicical imaging advanced to the capacity of cancer detection as the Magnetic Resonance Imaging (MRI) was developed by Armenian-born Dr. Raymond Damadian who performed the first full body scan to diagnose cancer and refining the focus of modern radiology.
The Bracco Imaging Group (headquartered in Milan, Italy) established the first multinational healthcare group in 1927, and heavily supported many contributions to clinical diagnostic science including the launch of the advancement of CONTRAST agents for all imaging solutions. It is this material injected in the bloodstream that allowed a significant improvement in identifying tumor cells.
ITALIAN HISTORY OF TRACKING BLOOD FLOW
Leonardo Da Vinci detailed over 500 years ago about the way the blood flowed in and out of the heart and showed how the valves worked. It wasn't until 1960 that the medical community caught up to Da Vinci and confirmed all this time that he was remarkably correct! A jump to the 1990's became a pivotal period as European imaging has standardized the non-invasive ultrasound technology to be a major screening protocol for cancer investigation.
PROF. RODOLFO CAMPANI
One of the leading pioneers in this study was Professor Rodolfo Campani who started the first world study of ultrasound contrast agents used in 1990 was first usable in the world on humans- was Schering Ag Levovist. The Scientific Journal ot the Italian Society of Radiology "La Radiologia Medica" (reported in May 1993) presented the results of the 5 Italian experimentation centers under his coordination at the Institute of Radiology in the University of Pavia. He was credited for developing the first (non-radiation based) ultrasound contrast agent which are used to show BLOOD FLOW in tumors, elevating the power of the ultrasound to out-perform MRI's, X-rays and CT Scans. Implementation of this contrast was a generational leap in advantages because it made the tumor vascularity much more easily visible using the injectable and safe ultrasound contrast agent. Unlike the MRI contrasts (which contained heavy metals) the ultrasound contrast was comprised of air bubbles and microalbumin. In a 1994 journal, this contrast was first used in liver cancers where vascularity is highlighted inside the liver.
With this same time span, CARLO MARTINOLI, MD (Genoa) arose as another contributor to the widespread use of ultrasound technology by emphasizing the effects of ultrasound imaging of the musculoskeletal and peripheral nervous systems. He helped shape modern medical education to recognize and include the studies of ultrasound and musculoskeletal radiology and coauthored vital textbooks on the subject which are still in use today in over 22 countries.
With this same time span, CARLO MARTINOLI, MD (Genoa) arose as another contributor to the widespread use of ultrasound technology by emphasizing the effects of ultrasound imaging of the musculoskeletal and peripheral nervous systems. He helped shape modern medical education to recognize and include the studies of ultrasound and musculoskeletal radiology and coauthored vital textbooks on the subject which are still in use today in over 22 countries.
ITALIAN HISTORY OF TRACKING BLOOD FLOW
Leonardo Da Vinci detailed over 500 years ago about the way the blood flowed in and out of the heart and showed how the valves worked. It wasn't until 1960 that the medical community caught up to Da Vinci and confirmed all this time that he was remarkably correct! A jump to the 1990's became a pivotal period as European imaging has standardized the non-invasive ultrasound technology to be a major screening protocol for cancer investigation.
PROFESSOR LUIGI SOLBIATI worked in Busto Arsizio (Varese) and in Milano. He specialized in the study of blood flow of cancers and published his discoveries about the major differences between malignant and benign tumor vessels. This study helped to shape the way non-invasive imaging protocols like the newer Doppler sonography & MRI diagnostic techniques identify cancers. He pioneered ultrasound-guided aspiration biopsies (1979), ethanol injection (1983), radiofrequency ablation with cool-tip electrodes (1995) and microwaves (2009) of solid tumors and fusion imaging for the guidance of interventional procedures (2003)
Modern studies confirm that metastasis (the spread of cancer to other areas of the body) and cell migration is mobilized by blood flow, and it is here that diagnostic protocols examine other clues as to the condition of the existing tumors. Digital ultrasound imaging with blood flow technology, the doppler blood flow, and the contrast enhanced blood flow was pioneered and developed by Rodolfo Campani and Luigi Solbiati (from Busto Arsizio/Varese) where they introduced worldwide the performance of the Doppler Ultrasound as a viable and more accurate technology for diagnosing tumors and assessing tumor response in many different areas.
(End of part 1)
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About the Author:
Robert L. Bard, MD, PC, DABR, FASLMS is internationally known and recognized as a leader in the field of 21st Century 3-D ULTRASONOGRAPHIC VOLUMETRIC DOPPLER IMAGING. Dr. Bard specializes in advanced 3-D sonography to detect cancers in numerous organs including the breast, prostate, skin, thyroid, melanoma and other areas. Dr. Bard’s images are used to accurately guide biopsies, target therapy and provide focused follow-up after treatment. As of Jan '18, Dr. Robert Bard spearheaded a partnership with a host of cancer educators, medical practitioners and non-profit foundations (allied under AwarenessforaCure.org) to form a public resource program to aid in the advancement of the public's understanding about self-preservation from cancer and other chronic diseases. EARLY DETECTION & PREVENTION is a global health movement that promotes a higher regard for "clean living" - from toxins and a toxic lifestyle. Our program consists of four main efforts: EDUCATION, COMMUNITY CONNECTION, CURRENT NEWS & CLINICAL RESOURCES. EARLY DETECTION & PREVENTION brings the empowerment of wellness through group seminars, videos and the distribution of current articles & newsletters published/shared to all the major cancer charities and their members. For more information or to subscribe to our EARLY CANCER DETECTION & PREVENTION PROGRAM newsletter, contact Bard Cancer Diagnostics today at: 212.355.7017 (www.BardCancerDiagnostics.com)- or email us at: bardcancercenter1@gmail.com
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Special thanks to the Columbia Association (FDNY) for their interest in exploring the history of cancer treatment and Italian solutionists. 5/14/2019 New Hyde Park, NY -- Chapter VP John Signorile introduces NYCRA's cancer advocates to present topics of awareness and available resources for checkups. In support of the Italian Heritage that the Columbia Association supports throughout its history, Dr. Bard produced this article as a gift to the organization and community it represents - uncovering the highly notable Italian contributors to cancer research. This archive study continues to expand in future volumes and issues.
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
Leonardo Da Vinci detailed over 500 years ago about the way the blood flowed in and out of the heart and showed how the valves worked. It wasn't until 1960 that the medical community caught up to Da Vinci and confirmed all this time that he was remarkably correct! A jump to the 1990's became a pivotal period as European imaging has standardized the non-invasive ultrasound technology to be a major screening protocol for cancer investigation.
PROFESSOR LUIGI SOLBIATI worked in Busto Arsizio (Varese) and in Milano. He specialized in the study of blood flow of cancers and published his discoveries about the major differences between malignant and benign tumor vessels. This study helped to shape the way non-invasive imaging protocols like the newer Doppler sonography & MRI diagnostic techniques identify cancers. He pioneered ultrasound-guided aspiration biopsies (1979), ethanol injection (1983), radiofrequency ablation with cool-tip electrodes (1995) and microwaves (2009) of solid tumors and fusion imaging for the guidance of interventional procedures (2003)
Modern studies confirm that metastasis (the spread of cancer to other areas of the body) and cell migration is mobilized by blood flow, and it is here that diagnostic protocols examine other clues as to the condition of the existing tumors. Digital ultrasound imaging with blood flow technology, the doppler blood flow, and the contrast enhanced blood flow was pioneered and developed by Rodolfo Campani and Luigi Solbiati (from Busto Arsizio/Varese) where they introduced worldwide the performance of the Doppler Ultrasound as a viable and more accurate technology for diagnosing tumors and assessing tumor response in many different areas.
(End of part 1)
..................................................................................................................................................................
About the Author:
Robert L. Bard, MD, PC, DABR, FASLMS is internationally known and recognized as a leader in the field of 21st Century 3-D ULTRASONOGRAPHIC VOLUMETRIC DOPPLER IMAGING. Dr. Bard specializes in advanced 3-D sonography to detect cancers in numerous organs including the breast, prostate, skin, thyroid, melanoma and other areas. Dr. Bard’s images are used to accurately guide biopsies, target therapy and provide focused follow-up after treatment. As of Jan '18, Dr. Robert Bard spearheaded a partnership with a host of cancer educators, medical practitioners and non-profit foundations (allied under AwarenessforaCure.org) to form a public resource program to aid in the advancement of the public's understanding about self-preservation from cancer and other chronic diseases. EARLY DETECTION & PREVENTION is a global health movement that promotes a higher regard for "clean living" - from toxins and a toxic lifestyle. Our program consists of four main efforts: EDUCATION, COMMUNITY CONNECTION, CURRENT NEWS & CLINICAL RESOURCES. EARLY DETECTION & PREVENTION brings the empowerment of wellness through group seminars, videos and the distribution of current articles & newsletters published/shared to all the major cancer charities and their members. For more information or to subscribe to our EARLY CANCER DETECTION & PREVENTION PROGRAM newsletter, contact Bard Cancer Diagnostics today at: 212.355.7017 (www.BardCancerDiagnostics.com)- or email us at: bardcancercenter1@gmail.com
..................................................................................................................................................................
Special thanks to the Columbia Association (FDNY) for their interest in exploring the history of cancer treatment and Italian solutionists. 5/14/2019 New Hyde Park, NY -- Chapter VP John Signorile introduces NYCRA's cancer advocates to present topics of awareness and available resources for checkups. In support of the Italian Heritage that the Columbia Association supports throughout its history, Dr. Bard produced this article as a gift to the organization and community it represents - uncovering the highly notable Italian contributors to cancer research. This archive study continues to expand in future volumes and issues.
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
Saturday, May 25, 2019
VETERINARY STEM CELL SPECIALIST PAVES THE WAY FOR HUMAN TREATMENT PROTOCOLS
INTRODUCTION
Our modern medical science owes a great debt to the veterinary community and the animal kingdom for the early treatment discoveries and advancements of STEM CELL research. The science of regenerative medicine started in 1981 from early mouse embryos, which led to the development of growing cells in laboratories. Today, the use of stem cells in humans is still considered experimental, while veterinary medicine has outnumbered human cases with the vast number of animals treated successfully. [1]
We reached out to Veterinarian and leading Stem Cell expert, Dr. Michael Hutchinson (PA) who has performed more than 1500 Adipose-Derived Stem Cell procedures on dogs, cats, horses, camels and a bird, among his 20,000 surgeries in 33 years of practicing veterinary medicine. His insights on this healing marvel for animals have proven its value in the preservation of life and wellness recovery- such that its growing popularity in the treatment of pets can reflect many similarities and future successes in humans to foster acceptance and confidence as a proven treatment option.
LEADING THE PATH FOR GENERAL USE
Interview with Dr. Michael Hutchinson
In 2005, I had a Saturday morning radio program in Pittsburgh where I focused on topics that interested me. I was intrigued by a laboratory from CA who showed some success with stem cells in horses first, and then dogs & cats. They were introducing this science only to specialists in the veterinary field, but it was my persistence in letter writing that encouraged them to offer this to general practitioners (including myself).
By 2008, I treated my first dog, and soon after, I started getting invited to treat horses (something I was quite familiar with out in Long Island from '86 to '98). I had experience with farm animals in my background, so I was interested in stem cells for all the issues that we saw in animals. It didn't matter if it was a bird or a horse - I was interested in getting these repair cells out and helping these animals with maladies that were not being treated very well with the standard of care. This failure of the standard of care led me down the road of clinical research where we started doing studies on kidney disease, degenerative myelopathy (similar to Lou Gehrig's disease or ALS), liver disease, arthritis and autoimmune diseases where the immune system would attack the body.
Over time, we expanded to the use of blood stem cells. A doctor and researcher from Melbourne, AU- Dr. Vasilis Paspaliaris, developed a system to harvest significantly higher-level microscopic stem cells out of the blood. He offered me to compassionately try it in animals for different conditions, especially those related to liver disease, kidney disease, and some degenerative nerve issues. This new blood protocol expanded my compassionate use in clinical trials for diseases that did not adequately respond to the fat-derived stem cells.
By 2010, my research has led me to align with MediVet Biologics for their impressive work with adipose-derived cells. Their research and continued advancements earned my trust to help pave the way in this study. MediVet’s procedure kit was considered a major scientific breakthrough for many disorders like osteoarthritis, hip dysplasia, ligament and cartilage injuries.
Patients journey from all over to experience the results of stem cell treatments for their pets. They suffer a wide range of issues from neurological deficits, autoimmune disorders to musculoskeletal damage. People who have had no success with other therapies are even willing to travel from different places in the US to have this available to them. Then we follow these treated animals to see if we're going to be able to help more animals or share protocols with the human side - which is my ultimate goal.
SUCCESS RATE VS. DISPELLING THE ALL-CURE MYTH
Importantly, stem cell therapy is not a panacea and is not meant for every condition out there. I don't think we veterinarians and doctors should be treating everything; I think we should be very mindful that we have reasonable expectations before recommending stem cell treatments. There is a finite list of disorders with pets that I am relatively confident in treating. One of them is Osteoarthritis (OA). It's the predominant condition that I manage utilizing fat-derived stem cells with dogs and evaluating symptoms for this is relatively cut and dry. If your dog is having trouble going up and down the steps, getting in and out of the car, going to the bathroom in one place, exhibiting pain and discomfort in joints or having trouble getting up from a laying down position, those are the telltale signs for OA.
Upon examination, if the animal is experiencing these symptoms and is showing no other issues, then I have a reasonable expectation (90%) that your dog's going to respond very well. Of course, not every osteoarthritis case will end the same, but we can predict with a very high expectation that we're going to have success. I base this on over 1,500 treatments, and the majority of them are Osteoarthritis.
When I treat this type of case, I inject the joints with stem cells after extracting and processing the fat (surgery to collect fat takes about 15 minutes and the processing an additional 2 - 3 hours). I would primarily choose fat stem cells, or MSCs (mesenchymal stem cells) to treat OA. They're the number one cell that's researched and published around the globe. You get them out of bone marrow, fat or several tissue types, but it's fat that shows the highest harvest numbers.
If I'm treating Osteoarthritis, these MSC's come out of the same germ layer (Mesoderm) as the cartilage, as the tendons, as the ligament- as the bone…and because it comes out of the same germ layer, it's a more logical repair cell to use, especially if you're hoping to achieve some regeneration of cartilage along the affected joints. We can also administer the cells through the use of a Hema-filter and an intravenous catheter… we're talking about (their own) autologous cells, so there is no risk of rejection. Since these stem cells are similar in size to the red blood cells, they can easily cross the blood-brain barrier and potentially help with the pain centers as well. We may not always get cell regeneration, but we almost always get a profound anti-inflammatory and immune-modulatory effect that lasts around a year and a half on average. Now, if I have a severely arthritic dog, maybe it was an athlete and had several injuries throughout its life, that dog may require more than one treatment that may not last as long as a year and a half. It may last six to eight months. However, I call it my "Gold Therapy" because it's profoundly better than the standard of care in many cases.
(End of part 1)
1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917716/
2) Dr. Mike Hutchinson (website)- http://drmikehutchinson.com/
3) MediVet Biologics (website) http://medivetbiologics.com/about-us/
...............................................................................................................................................................
About "Dr. Mike" Hutchinson-
A leading practitioner in stem cell therapy, Dr. Mike Hutchinson, DVM, is a highly sought after speaker at national and international veterinary conferences on the uses of animal stem cells. He also has co-authored "Discussion of Animal Stem Cells in the Classroom: Engaging Students through the Lens of Veterinary Medicine", published in The American Biology Teacher, and co-authored a study on Serotypes of Bovine Astrovirus, published in the Journal of Clinical Microbiology. He is the owner of Animal General of Cranberry and Chairman of the Board of VivaTech International, Dr. Mike is married and the father of five children. For additional interviews, you may contact Dr. Mike Hutchinson at 724-776-7930
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
Our modern medical science owes a great debt to the veterinary community and the animal kingdom for the early treatment discoveries and advancements of STEM CELL research. The science of regenerative medicine started in 1981 from early mouse embryos, which led to the development of growing cells in laboratories. Today, the use of stem cells in humans is still considered experimental, while veterinary medicine has outnumbered human cases with the vast number of animals treated successfully. [1]
We reached out to Veterinarian and leading Stem Cell expert, Dr. Michael Hutchinson (PA) who has performed more than 1500 Adipose-Derived Stem Cell procedures on dogs, cats, horses, camels and a bird, among his 20,000 surgeries in 33 years of practicing veterinary medicine. His insights on this healing marvel for animals have proven its value in the preservation of life and wellness recovery- such that its growing popularity in the treatment of pets can reflect many similarities and future successes in humans to foster acceptance and confidence as a proven treatment option.
LEADING THE PATH FOR GENERAL USE
Interview with Dr. Michael Hutchinson
In 2005, I had a Saturday morning radio program in Pittsburgh where I focused on topics that interested me. I was intrigued by a laboratory from CA who showed some success with stem cells in horses first, and then dogs & cats. They were introducing this science only to specialists in the veterinary field, but it was my persistence in letter writing that encouraged them to offer this to general practitioners (including myself).
By 2008, I treated my first dog, and soon after, I started getting invited to treat horses (something I was quite familiar with out in Long Island from '86 to '98). I had experience with farm animals in my background, so I was interested in stem cells for all the issues that we saw in animals. It didn't matter if it was a bird or a horse - I was interested in getting these repair cells out and helping these animals with maladies that were not being treated very well with the standard of care. This failure of the standard of care led me down the road of clinical research where we started doing studies on kidney disease, degenerative myelopathy (similar to Lou Gehrig's disease or ALS), liver disease, arthritis and autoimmune diseases where the immune system would attack the body.
Over time, we expanded to the use of blood stem cells. A doctor and researcher from Melbourne, AU- Dr. Vasilis Paspaliaris, developed a system to harvest significantly higher-level microscopic stem cells out of the blood. He offered me to compassionately try it in animals for different conditions, especially those related to liver disease, kidney disease, and some degenerative nerve issues. This new blood protocol expanded my compassionate use in clinical trials for diseases that did not adequately respond to the fat-derived stem cells.
By 2010, my research has led me to align with MediVet Biologics for their impressive work with adipose-derived cells. Their research and continued advancements earned my trust to help pave the way in this study. MediVet’s procedure kit was considered a major scientific breakthrough for many disorders like osteoarthritis, hip dysplasia, ligament and cartilage injuries.
Patients journey from all over to experience the results of stem cell treatments for their pets. They suffer a wide range of issues from neurological deficits, autoimmune disorders to musculoskeletal damage. People who have had no success with other therapies are even willing to travel from different places in the US to have this available to them. Then we follow these treated animals to see if we're going to be able to help more animals or share protocols with the human side - which is my ultimate goal.
SUCCESS RATE VS. DISPELLING THE ALL-CURE MYTH
Importantly, stem cell therapy is not a panacea and is not meant for every condition out there. I don't think we veterinarians and doctors should be treating everything; I think we should be very mindful that we have reasonable expectations before recommending stem cell treatments. There is a finite list of disorders with pets that I am relatively confident in treating. One of them is Osteoarthritis (OA). It's the predominant condition that I manage utilizing fat-derived stem cells with dogs and evaluating symptoms for this is relatively cut and dry. If your dog is having trouble going up and down the steps, getting in and out of the car, going to the bathroom in one place, exhibiting pain and discomfort in joints or having trouble getting up from a laying down position, those are the telltale signs for OA.
Upon examination, if the animal is experiencing these symptoms and is showing no other issues, then I have a reasonable expectation (90%) that your dog's going to respond very well. Of course, not every osteoarthritis case will end the same, but we can predict with a very high expectation that we're going to have success. I base this on over 1,500 treatments, and the majority of them are Osteoarthritis.
When I treat this type of case, I inject the joints with stem cells after extracting and processing the fat (surgery to collect fat takes about 15 minutes and the processing an additional 2 - 3 hours). I would primarily choose fat stem cells, or MSCs (mesenchymal stem cells) to treat OA. They're the number one cell that's researched and published around the globe. You get them out of bone marrow, fat or several tissue types, but it's fat that shows the highest harvest numbers.
If I'm treating Osteoarthritis, these MSC's come out of the same germ layer (Mesoderm) as the cartilage, as the tendons, as the ligament- as the bone…and because it comes out of the same germ layer, it's a more logical repair cell to use, especially if you're hoping to achieve some regeneration of cartilage along the affected joints. We can also administer the cells through the use of a Hema-filter and an intravenous catheter… we're talking about (their own) autologous cells, so there is no risk of rejection. Since these stem cells are similar in size to the red blood cells, they can easily cross the blood-brain barrier and potentially help with the pain centers as well. We may not always get cell regeneration, but we almost always get a profound anti-inflammatory and immune-modulatory effect that lasts around a year and a half on average. Now, if I have a severely arthritic dog, maybe it was an athlete and had several injuries throughout its life, that dog may require more than one treatment that may not last as long as a year and a half. It may last six to eight months. However, I call it my "Gold Therapy" because it's profoundly better than the standard of care in many cases.
(End of part 1)
1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917716/
2) Dr. Mike Hutchinson (website)- http://drmikehutchinson.com/
3) MediVet Biologics (website) http://medivetbiologics.com/about-us/
...............................................................................................................................................................
About "Dr. Mike" Hutchinson-
A leading practitioner in stem cell therapy, Dr. Mike Hutchinson, DVM, is a highly sought after speaker at national and international veterinary conferences on the uses of animal stem cells. He also has co-authored "Discussion of Animal Stem Cells in the Classroom: Engaging Students through the Lens of Veterinary Medicine", published in The American Biology Teacher, and co-authored a study on Serotypes of Bovine Astrovirus, published in the Journal of Clinical Microbiology. He is the owner of Animal General of Cranberry and Chairman of the Board of VivaTech International, Dr. Mike is married and the father of five children. For additional interviews, you may contact Dr. Mike Hutchinson at 724-776-7930
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
Monday, May 6, 2019
Essentials of Cancer Prevention & Early Detection- by: Dr. Jesse Stoff
This presentation was written and delivered by Dr. Jesse A. Stoff, Immunology Specialist at the 2019 Male Breast Cancer Coalition Conference. It covers the major fundamentals that you can do to reduce your risk of getting cancer or a recurrence of cancer.
Nowadays, most cancers are initiated or triggered, by a
toxin. Toxins, in high enough levels of concentration and the right type, can lead
to cancer spikes in various populations. In the place where I live on Long
Island, New York, it is known as a cancer cluster. We have the highest
instances of breast and prostate cancer and the highest instances of thyroid
disease in the United States. Other
places that are notable for cancer spikes are the infamous Love Canal. It
brings back many memories for people. Nonetheless on Long Island, we have to
deal with the toxins that were dumped there from Grumman and Fairchild Hiller
and other members of the aerospace industry primarily during World War II.
Toxins are the number one cause of cancer initiation. It's
toxins that get people into trouble in terms of cancer. The kind of toxins that we are worried about
are the petrochemicals, volatile organic hydrocarbons and heavy metals are on
the top of the list.
What these toxins do is they can interact in several places
in the sequence to initiate the activity of this particular enzyme called
COX-2. This is a major enzyme that leads to an inflammatory response in the
body. There are many toxins that can directly trigger the activity of COX-2 in
the production of this Prostaglandin or PGE2 which
ultimately leads to activation of the ERa receptor. There are two major
receptors that are involved in transmission and information of estrogen, ERa
and ERb. ERa is one that ultimately through activation of this enzyme and the CYP1B.
These two add to the production of four hydroxy netradyle and the initiation of
breast cancer.
Now, the initiation of a cancer does not mean that
the person is actually going through to develop that disease, and that's very
important, because initiation is just one step in the whole process. Once the
cancer has been initiated, they only have issues of promotion and progression
before they actually have a major problem. When we're looking at issues of
promotion and progression, we're not talking about the toxins anymore. What
we're talking about is the internal biochemistry of the individual. That's when
it has an impact on the ability of the body to stop the cancer, to reverse the
early cancers and to prevent the progression. All of us produce a certain
number of cancer cells every day.
Many of you who have had cancer know about blood tests for
tumor markers. And if you've ever looked at the normal range of a tumor marker,
you'll see that the normal range is not 0 to 0. It's 0 to some number. And the
reason is because all of us produce a certain number of cancer cells. Through
the activity of our immune system, it destroys those cells. It identifies and
destroys them and releases these proteins into the blood that we can measure as
tumor markers, and we all run low levels of these things.
It's only when the immune system can't identify the abnormal
cells anymore that they're allowed to progress into a cancer. The risk of
getting cancer or the risk of getting a recurrence of cancer is inversely
related to the health, strength and structure of your immune system. So, that's
something to keep in mind because we're trying to prevent future problems.
As mentioned earlier, toxins are the number one
way that cancers get initiated, and one of the things you might think about
doing are some basic detox things on a regular basis. A simple Google search will get you started
on this path to better health. As one example of many, you’ll find that plastic
bottles are not the best form of bottle water. Glass is better because if
plastic bottles get hot, they can breakdown a little bit and create some
issues, but it's better than what comes out of the tap around here.
A recent article that came out December of 2018 in
JAMA (the Journal of the American Medical Association) that looked at organic
foods in terms of cancer prevention. They concluded that eating an organic diet decreased the risk and risk of recurrence of
all known cancers. An organic diet means you’re basically avoiding the
toxins that could be cancer initiators, but you're also eating a diet that has
a much higher nutrient density that your body needs in order to function and work
properly.
For cancer to progress, it has to be a certain
amount of genetic instability. Some common supplements include:
- Vitamin D3
- Indole-3-Carbinol
- Curcumin
- Supforaphane
- Fish Oil
- Green Tea
- IV’s
There are others- and they act as genetic stabilizers. These
things can help to limit, stop and reverse the progression of cancers in the
different stages of this plasia, metaplasia, neoplasia, etc.
So, the progression of cancer isn't based upon the
initiation, it's based upon the internal value chemistry of the person who's
fighting it off. And these are some of the things that can stabilize those
genetics.
Now, blood tests can give us a rough idea of where
we are because the blood test will tell us about our internal biochemistry.
There are four biochemical pathways that allow a cancer to progress, and those
four pathways are oxidation, glycation, methylation and inflammation. So, here
we have:
- glycation
- oxidation
- methylation
- and inflammation
Now, as mentioned earlier, the risk of getting
cancer or recurrence is based upon the structure and function of the immune
system. These are some very simple basic tests that one can order, any doctor
can order these to see where you stand in that whole risk of cancer issues.
Some essential things that you should start doing
today to modify your risk of getting cancer or a recurrence of cancer.
Water Testing & Filtration: First,
go to www.EWG.org- and find out what's in
your water. This is a free website with a national database then find out what
the appropriate filter is that you need to get in order to filter that stuff
out. There are many filters on the market and there are several that I like but
nonetheless, the filter that you use should be tied to the toxins that you're
exposed to.
Organic diet: This is critical. See (link)
Toxic Non-Metal Chemical test & Chelation: We want to start finding out what's already in your system so we can do something about it. GPL-TOX PROFILE (Toxic Non-Metal Chemicals text) is one of many tests that are available that looks at nonmetal chemicals. Nonmetal chemicals that are toxins or are carcinogenic are basically the volatile organic hydrocarbons and this will test for 172 of them. If you find these things in your system, there are different medical things that can be done to chelate these things out and pull them out of your system before they have a chance to initiate a cancer.
Urine Test: When we're looking at heavy
metals, visit www.doctorsdata.com. This is a urine
test, very simple test that your doctor can order to see what heavy metals in
your system are there that can, again, be carcinogenic and initiators of
cancer. If you find that these things are in your system, you want to pull them
out before you have a lump.
Comprehensive Toxicology Test: Next, if
you've been exposed to some chemicals or toxins that aren't on the previous
list, this is a national reference laboratory for toxicology, the number one in
the country. (www.nmslabs.com). They test for
over 2500 different things, but at that point, it's a very specific test that
you're ordering. So, if you know that you've been exposed to a certain chemical
or toxin, you want to see to what extent it may be in your system, this test
will tell you the answer.
Toxicity Result/Data Research: Now, if
you've been exposed to a certain chemical or toxin as we all have and you find
it's in your system and you're concerned about what it might do to you, this is
a website (www.toxnet.nlm.nih.gov) run
by our government. In the search bar, put in immune system and whatever that
chemical is and find out what it does to your immune system because the immune
system again is the part of our biochemistry that keeps us out of trouble
relative to cancer. And you can also put in as a search term the name of that
chemical and the word cancer. But you have to put in the work and in order for
it to do an accurate search for you.
Confirmation
Screening tests: If you're concerned from a screening point of view as to
whether or not you already have cancer cells in your body, IVYGENE is an
advanced blood test that performs like a liquid biopsy, and it looks for a
specific change in genetics that indicate the activity of cancer cells. (www.ivygenelabs.com) FDA cleared the test
for breast cancer, lung cancer, colon cancer and liver cancer. If it comes back
elevated, please get yourself screened and find out where it is. This is all
part of early detection. They expect by the end of this year they'll be FDA
cleared for over a dozen different cancers. There are other companies that are
working on developing even more sophisticated versions of liquid biopsies, but
at this point, this is the only game in town.
THE PLAN
Start with Detox,
Water and Organic diet. Target improved
nutrition and acquire supplements
that can stabilize the genetics if it seems you are at higher risk. Lab tests to check your biochemistry
and immune system for a shift in structure & function. Lab test for different toxins. Liquid
biopsy- (IvyGene) which happens
to be the only one on the market that looks for the activity of cancer cells
before they have formed a tumor.
Lifestyle of
course, plays a risk in terms of developing cancer, toxin exposure, stress and
increase in levels of inflammation in the body. So, engage in activities that
modify your level of stress. The two easiest ways of dealing with stress is
sleep- particularly the sleep before midnight. The other way to easily deal
with stress is by doing things for fun. Now, in medicine, we have a definition
for everything. Fun is defined as doing something for the experience and not
the outcome.
If the liquid biopsy comes back positive, we have
screening exams, ultrasounds, mammograms, MRIs, physical exams. And the point of all of this
that I'm sharing with you today is to reduce your risk now and in the future
about getting any sort of cancer or recurrent if you've already had it so that
you can live long and prosper.
................................
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
................................
Disclaimer & Copyright Notice: The materials provided on this website are copyrighted and the intellectual property of the publishers/producers (The NY Cancer Resource Alliance/IntermediaWorx inc. and Bard Diagnostic Research & Educational Programs). It is provided publicly strictly for informational purposes within non-commercial use and not for purposes of resale, distribution, public display or performance. Unless otherwise indicated on this web based page, sharing, re-posting, re-publishing of this work is strictly prohibited without due permission from the publishers. Also, certain content may be licensed from third-parties. The licenses for some of this Content may contain additional terms. When such Content licenses contain additional terms, we will make these terms available to you on those pages (which his incorporated herein by reference).The publishers/producers of this site and its contents such as videos, graphics, text, and other materials published are not intended to be a substitute for professional medical advice, diagnosis, or treatment. For any questions you may have regarding a medical condition, please always seek the advice of your physician or a qualified health provider. Do not postpone or disregard any professional medical advice over something you may have seen or read on this website. If you think you may have a medical emergency, call your doctor or 9-1-1 immediately. This website does not support, endorse or recommend any specific products, tests, physicians, procedures, treatment opinions or other information that may be mentioned on this site. Referencing any content or information seen or published in this website or shared by other visitors of this website is solely at your own risk. The publishers/producers of this Internet web site reserves the right, at its sole discretion, to modify, disable access to, or discontinue, temporarily or permanently, all or any part of this Internet web site or any information contained thereon without liability or notice to you.
Friday, May 3, 2019
"Armchair Seminars": The New Trend in Public Education
We've talked about doing a public speaking event for quite some time", says Dr. Rochman. "Finding the right location and setting defines the very personality of the message and until now, we couldn't come up with that proper venue that made sense for this topic. When you think about Stem Cell being a very modern yet exploratory science targeting such a wide range of patient types, ages, lifestyles and cultures... I couldn't see this happening in a classroom or a corporate theater. Knowing this audience, that type of setting would evoke so much stuffiness and tension to the message whereas bringing this into a home setting level (like what we did) allowed us to go from academic & clinical dialogue into a sharing circle- capturing the same nuance of visiting your uncle's house."
two week lead time, Dr. Rochman's office contacted as far back as four months worth of phone inquirers. Men and women of all ages often connect from his website (
Thanks to the recent revolution in information (web) access, exploring new modalities for pain relief has become so much easier. Medical speaking events and private seminars like this one certainly help the overall decision-making process, but the average attendee came with a certain amount of collective knowledge about the topic before walking in the door as reflected by the questions they asked. Event promoter Robyn Stimmel donated her lovely suburban abode (Dix Hills, NY) to this educational experiment. "Personally, attending a seminar of this intensity should be in an atmosphere that's comfortable in its surroundings. I volunteered my home to have Dr. Rochman deliver this Regenative Medicine seminar because it felt like a good match with his warm and engaging presence. We got great positive feedback about the intimacy from the cozy environment we created!"
A SPECIAL AUDIENCE AND THE RIGHT ATMOSPHERE
Dr. Rochman's event team explored a bevy of options for the launch of this speakere series. Understanding this type of audience plays a major role in the design of this educational program -including the use of Ms. Stimmel's home. "The very topic of stem cell tends to attract fairly educated individuals who are active in researching for better answers", states Dr. Rochman. "This is a grown-up crowd who have significant health concerns. With those concerns also come a certain level of disappointment and distrust in prior treatment solutions... and the last thing they need is to be 'talked down to' with more pedantic medical jargon. The same way I talk to any of my patients, this audience deserves real education and down-to-earth facts that anyone can understand."
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Dr. Andrew J. Rochman is a NY Board-Certified Surgeon and a leader in advanced surgical techniques. He is a graduate of Colgate University and received his formal medical training from Nordestana University in 1981. He is an active member of the American Medical Association, the Medical Society of the State of New York, Nassau County Medical Society and the American College of Phlebology. Dr. Rochman currently manages several practices in the specialized sciences of advanced vein therapy, gallbladder surgery and stem cell therapy. For more information on his current practice, visit: www.DrAndrewJRochman.com
DISCLAIMER:
All articles posted in this blogsite include their own content reference links identifying where information of each article are sourced. We do not claim that these treatments work for any listed nor unlisted condition, intended or implied. Dr. Andrew J. Rochman, "Cellular Therapies of NY",its employees and agents, assert no claims regarding the efficacy or appropriateness of any form of treatment mentioned In our blog site and other programs whereby we not promoting cell regenerative (stem cell) therapy as a cure for any condition, disease, or injury. No statements on this blog site have been evaluated or approved by the FDA. This blog site contains no medical advice whereas all statements and opinions provided are for the sole intent of educational, informational or editorial purposes only and we (the writers & publishers) do not make claims to diagnose or treat via this blogsite or other communication means. Cellular Therapies of NY, Dr. Andrew J. Rochman does not claim that any applications or potential applications using stem cells are approved by the FDA, or are even effective. It’s important for potential patients to do their own research based on the options that we present so that one can make an informed decision. If you have ANY concerns with Cellular Therapies of NY, Dr. Andrew J. Rochman’s methods, this blog site, or technique, please contact us at 516-280-1333 so that we can investigate the matter or concern immediately.
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